
SILVAN ANTIBACTERIAL BIOMETAL TECHNOLOGY
* Trampuz A, Zimmerli W. Diagnosis and treatment of infections associated with fracture-fixation devices. Injury 2006;37:S59–S66.
1> 药物治疗:抗生素联合使用——注射+口服
2> 手术治疗:取出植入物——配合使用外固定及药物
3> 局部治疗:局部使用高浓度抗生素——已发现肾毒性风险*
* Patrick BN, Rivey MP, Allington DR. Acute renal failure associated with vancomycin- and tobramycin-laden cement in total hip arthroplasty. Ann Pharmacother 2006;40:2037–2042.

采用具有生物功能性的创新医用金属材料从根本上解决植入物手术后感染和愈合的问题。


* Y. Zhuang, L. Ren, S. Zhang et al., Antibacterial effect of a copper-containing titanium alloy against implant- associated infection induced by methicillin-resistant Staphylococcus aureus, Acta Biomaterialia, https://doi.org/10.1016/j.actbio.2020.10. 026

- 45只大鼠体内试验
- 植入普通/抗菌钛合金棒
- 植入物表面覆盖细菌液
- 不使用抗生素处理
* Y. Zhuang, L. Ren, S. Zhang et al., Antibacterial effect of a copper-containing titanium alloy against implant- associated infection induced by methicillin-resistant Staphylococcus aureus, Acta Biomaterialia, https://doi.org/10.1016/j.actbio.2020.10. 026
- 54只大鼠
Sham: n=5, Sham-Ti: n=15
OVX-Ti: n=15, OVX-TiCu: n=19
- 卵巢切除建立骨质疏松模型
- 螺钉植入后腿胫骨内侧
- 成血管实验与成骨实验
Sham:假手术组
Sham-Ti:健康组植入普通螺钉
OVX-Ti:卵巢切除组植入普通螺钉
OVX-TiCu:卵巢切除组植入抗菌螺钉


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